Dr. Papiya Majumdar, PhD, Chemistry, University of Missouri-Columbia, USA
Asst. Prof., Dept. of Chemistry, Sister Nivedita University; Faculty-in-Charge extracurricular activities, Sister Nivedita University
Educational Qualification:
Ph.D. (Organic Chemistry), University of Missouri-Columbia, MO, USA.
Area of Research and Research Interests:
1. Organic Chemistry and Biotechnology: exploring the role of DNA repair enzyme tyrosyl DNA phosphodiesterase 1 (TDP1) as a co-target with human topoisomerase I (Top1) in anti-cancer therapy.
2. Different chemical compound/drug assay to find out potent Leishmania donovani (LdTop1) and human topoisomerase I (Top1) inhibitor/s.
Post-doctoral Experience:
1. Nov 2013 – Dec 2015: CSIR-Senior Research Associate (SRA: Scientist Pool Scheme) at CSIR-Indian Institute of Chemical Biology.
2. Feb 2013 – Oct 2013: Research Associate under the “Raja Ramanna Fellowship Scheme” in Dept of Infectious disease and Immunology, Indian Institute of Chemical Biology, Kolkata
3. June 2007 – April 2009: Post-doctoral Fellow at University of California-San Diego, USA.
Specialization/Domain Area:
Organic Chemistry and Biotechnology
HONORS & AWARDS:
- 2005 and 2006: Professional Presentation Travel Fellowship Award, MU, USA.
- 2005 and 2006: GPC (Grad. Prof. Council) Travel Scholarship Award, MU, USA.
- 2013: Senior Research Associate-ship Award (CSIR-Pool Officer) from Council of Scientific & Industrial Research (CSIR), Govt. of India.
Experience in Education/Academia: Total 10 years’:
3 years full time faculty member at Sister Nivedita University, India
1 year as adjunct faculty member at Adamas University, India
6 years as Teaching Assistant in University of Missouri Columbia, USA
Teaching Area:
Organic Stereochemistry, Organic Synthesis, Organic Spectroscopy, Reaction Mechanisms, Chemistry of Aliphatic and Aromatic Hydrocarbons
Cumulative Industry/Research Experience: Total 11 years’:
6 Years at University of Missouri-Columbia, USA as PhD Scholar (2001-2007)
1 years 10 months at University of California-San Diego, USA as Post-Doc Research Scholar (2007-2009)
3 years at CSIR-Indian Institute of Chemical Biology, Kolkata as SRA (2013-2015)
2 months at Tata Pharma Ltd., Mumbai (1998)
Selected Publications in Peer Reviewed Journals:
1. Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors. Rajinikanth Mamidala, Papiya Majumdar, Kunal Kumar Jha, Chandramohan Bathula, Rahul Agarwal, M. ThirumalaChary, H. K. Mazumdar, Parthapratim Munshi & Subhabrata Sen; accepted on 3rd May, 2016: Scientific Reports (Impact factor: 5.578)
2. Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells. Das, Subhendu; Rehman, Ishita; Ghosh, Arijit; Sengupta, Souvik; Majumdar, Papiya; Jana, Biman; Das, Benu Brata*: Accepted on July 13, 2016: Nucleic Acid Res (Impact factor: 9.112)
3. Design, synthesis and evaluation of thiohydantoin derivatives as Noncamptothecin Topoisomerase I (Top 1) Inhibitors. Papiya Majumdar, Chandramohan Bathula, Suparna M Basu, Subhendu K Das, Rahul Agarwal, Santanu Hati, Ashutosh Singh, Subhabrata Sen,*, Benu Brata Das*, European Journal of Medicinal Chemistry: accepted on August 15, 2015. (Impact factor: 3.447)
4. PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage
Das, Benu; Huang, Shar-yin N; Murai, Junko.; Rehman, Ishita; Amé, Jean-Christophe; Sengupta, Souvik; Das, Subhendu; Majumdar, Papiya; Zhang, Hongliang; Biard, Denis; Majumder, Hemanta; Schreiber, Valérie; Pommier, Yves, Nucleic Acid Res 2014, 42, 4435-49. (Impact factor: 9.112)
5. Ammonia Elimination from Protonated Nucleobases and Related Synthetic Substrates. Ming Qian, Shuo Yang, Hong Wu, Papiya Majumdar, Nathan Leigh, and Rainer Glaser, J. Am. Soc. Mass Spectrometry (JASMS) 2007, 18, 2040-2057. (Impact factor: 3.19)
6. Oxanosine is a Substrate of Adenosine Deaminase. Implications for the Quest for a Toxicological Marker for Nitrosation Activity. Papiya Majumdar, Hong Wu, Peter Tipton, and Rainer Glaser, Chem. Res. Tox. 2005, 18, 1830-1841. (Impact factor: 3.529)
7. 5-Cyanoimino-4-oxomethylene-4,5-dihydroimidazole and 5-cyanoamino-4-imidazole-carbo-xylic acid intermediates in nitrosative guanosine deamination. Evidence from 18O-labeling experiments. Sundeep Rayat, Papiya Majumdar, Peter Tipton, and Rainer Glaser, J. Am. Chem. Soc. 2004, 126, 9960-9969. (Impact factor: 12.113)
Selected Conference Publications & Paper Presentations:
1. Press Meet 2019 on 30th January, 2019 at Press Club: “How Cancer Starts, Grows, & Spreads” Dr. Papiya Majumdar, HOD of Chemistry, Sister Nivedita University; Prof. (Dr) Jahar Majumdar, CNCI; Dr. Ayan Basu, HOD, Radiation Oncology, HCG EKO Cancer Centre; Dt. Rohini Mondal, Diet Consultant, SD Medical Services & Consultancy.
2. “DNA topoisomerase I dynamics in living cells Nucleus: Both the N-terminal and the catalytic domain of human Top1 steers the Camptothecin sensitivity.” Papiya Majumdar , Subhendu K. Das, Souvik Sengupta, Tamalika Sanyal, Arijit Ghosh and Benu Brata Das; poster presentation, IABS-2015 (An Interdisciplinary Approach to Biological Sciences), Kolkata, February 2 & 3, 2015.
3. “DNA topoisomerase I dynamics in living cells: active site tyrosyl steers the CPT sensitivity.” Papiya Majumdar, Subhendu K. Das and Benu Brata Das; poster presentation, IACS (Indian Association for the Cultivation of Science), on National Science Day, Kolkata, February 28, 2014.
4. “Fasicularin-derived aziridinium ion: Theoretical study of the formation of the putative reactive nitrogen species.” Papiya Majumdar, Rainer Glaser; Sanjay Dutta and Kent S. Gates; poster presentation, 232nd American Chemical Society National Meeting, San Francisco, September 11 & 12, 2006.
5. “Nitrosative guanosine deamination: 17O-Labeling studies as integral accompaniment to 18O-studies.” Papiya Majumdar, and Rainer Glaser; poster presentation, 19th annual Organic Chemistry Day, University of Missouri-Columbia, April 29, 2006.
6. “Nitrosative guanosine deamination: 17O-Labeling studies as integral accompaniment to 18O-studies.” Papiya Majumdar, and Rainer Glaser; oral presentation, Research and Creative Activities Forum (RCAF), University of Missouri-Columbia, March 18, 2006.
7. “Oxanosine is a Substrate of Adenosine Deaminase: Identification and Characterization of the Reaction Product.” Papiya Majumdar, Hong Wu, Peter Tipton, and Rainer Glaser; poster presentation, XXV Midwest Enzyme Chemistry Conference, Loyola University, Chicago, October 8, 2005.
8. “Nitrosative guanosine deamination: 17O-Labeling studies as integral accompaniment to 18O-studies.” Papiya Majumdar, and Rainer Glaser; oral presentation, 230th American Chemical Society National Meeting, Washington D.C., August 29, 2005.
9. “Oxanosine is a Substrate of Adenosine Deaminase: Identification and Characterization of the Reaction Product.” Papiya Majumdar, Hong Wu, Peter Tipton, and Rainer Glaser; poster presentation, 18th annual Organic Chemistry Day, University of Missouri-Columbia, April 30, 2005.
10. “Oxanosine is a Substrate of Adenosine Deaminase: Identification and Characterization of the Reaction Product.” Papiya Majumdar, Hong Wu, Peter Tipton, and Rainer Glaser; poster presentation, 228th American Chemical Society National Meeting, Philadelphia, PA, August 24, 2004.