Dr. Somsubhra Thakur Choudhury
Ph.D. in Biochemistry from University of Calcutta (worked at CSIR-Indian Institute of Chemical Biology)
GATE 2010 in Life Science.
M.Sc. in Microbiology (H) from University of Calcutta.
B.Sc. in Microbiology (H) from University of Calcutta.
Teaching Experience: 2 years.
Teaching Area: Molecular Biology, Cell Biology and Cell signaling, Bacteriology, Drug Designing and Drug delivery.
Prof Thakur Choudhury is involved in research on two major areas. Drug delivery system deals with the delivery of a therapeutic agent to the specific site in our body. The therapeutic agents or drugs have long been used to improve our health, to fight against the diseases and providing us an extended life. But the majority of the therapeutic agents face some major drawbacks like toxicity, resistance and poor bioavailability. In this respect, the drug delivery technology has opened a new avenue to improve the therapeutic efficacy of the drug.
Prof. Thakur Choudhury’s research interest is to explore the drug delivery field specifically liposomal and nanoparticulated drug delivery. Primarily he wants to develop new formulations of conventional drugs to improve their therapeutic efficacy. In future, the prime objective will be to develop target specific delivery of cytotoxic drugs for critical diseases like cancer.
2. Diagnosis of a disease is very important for proper and timely medication. In recent years a major thrust in the field of research is to develop an easy as well as an efficient diagnostic tool for detection of disease. His objective is to develop easy, field adaptable diagnostic kits with higher sensitivity and specificity for the early detection of different infectious diseases as well as for different neurodegenerative diseases like Alzheimer’s and Parkinson.
“Design and Manufacture of Emergency Combat Kit for Covid-19” submitted to Technology Development Board, Department of Science and Technology, Govt. of India. This project is submitted jointly with Prof Rajat Pal.
List of Publications:
1. Choudhury ST, Das N, Ghosh S, Ghosh D, Chakraborty S and Ali N. (2016). Vesicular(liposomal and nanoparticulated) delivery of curcumin: a comparative study on carbontetrachloride mediated oxidative hepatocellular damage in rat model. Int JNanomedicine.11: 2179–2193.
2. Ejazi SA, Ghosh S, Saha S, Choudhury ST et al. (2019). A multicentric evaluation of dipstick test for serodiagnosis of visceral leishmaniasis in India, Nepal, Sri Lanka, Brazil, Ethiopia and Spain.Sci Rep.9;9(1):9932.
3. Ejazi SA, Bhattacharyya A, Choudhury ST, Ghosh S, Sabur A, Pandey K, Das VNR, Das P, Rahaman M, Goswami RP, Ali N. (2018). Immunoproteomic Identification and Characterization of Leishmania Membrane Proteins as Non-Invasive Diagnostic Candidates for Clinical Visceral Leishmaniasis.Sci Rep. 14;8(1):12110.
4.Ghosh S, Sarkar S, Choudhury ST, Ghosh T, Das N. (2017). Triphenyl phosphoniumcoated nano-quercetin for oral delivery: Neuroprotective effects in attenuating agerelated global moderate cerebral ischemia reperfusion injury in rats. Nanomedicine.13(8):2439-2450.
5. Maji M, Mazumder S, Bhattacharya S, Choudhury ST, Sabur A, Shadab Md,Bhattacharya P, Ali N. (2016). A lipid based antigen delivery system efficientlyfacilitates MHC Class-I antigen cross-presentation in dendritic cells to stimulate CD8+ TCell.Sci Rep. 2;6:27206.
6. Ghosh S, Dungdung SR, Choudhury ST, Chakraborty S, Das N. (2014). Mitochondriaprotection with ginkgolide B-loaded polymeric nanocapsulespreventsdiethylnitrosamine-induced hepatocarcinoma in rats. Nanomedicine (Lond). 9(3):441-456.
7. Chakraborty S, Stalin S, Das N, Choudhury ST, Ghosh S, Swarnakar S. (2012). Theuse of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation duringprevention of gastric inflammation induced by ethanol in rat. Biomaterials. 33(10):2991-3001.
8. Ghosh A, Ghosh D, Sarkar S, Mandal AK, Choudhury ST, Das N. (2012).Anticarcinogenic activity of nanoencapsulated quercetin in combatingdiethylnitrosamine-induced hepatocarcinoma in rats. Eur J Cancer Prev. 21(1): 32-41.
9. Ghosh D, Choudhury ST, Ghosh S, Mandal AK, Sarkar S, Ghosh A, Saha KD, Das N.(2012). Nanocapsulated curcumin: oral chemopreventive formulation againstdiethylnitrosamine induced hepatocellular carcinoma in rat. Chem Biol Interact.195(3): 206-214.
10. Ghosh S, Dungdung SR, Choudhury ST, Mandal AK, Sarkar S, Ghosh D, Das N.(2011). Encapsulation of the flavonoid quercetin with an arsenic chelator intonanocapsules enables the simultaneous delivery of hydrophobic and hydrophilic drugswith a synergistic effect against chronic arsenic accumulation and oxidative stress. FreeRadicBiol Med. 51(10): 1893-1902.
1. Choudhury ST, Ali N, Da N. Effect of Nanoparticulated Ellagic Acid in preventing Diethylnitrosamine mediated Hepatocellular Carcinoma in experimental animal model. 5th International Conference on Stem Cells and Cancer (ICSCC-2014). Organized by: International Centre for Stem Cells, Cancer and Biotechnology (ICSCCB). November, 2014.
2. Choudhury ST. Nanoparticulated curcumin induced Hepatopretection in Carbon Tetrachloride mediated oxidative liver damage. International Symposium on Emerging trends in Free Radicals, Antioxidants and nutraceuticals on Health Disease and Radiation Biology. Organized by: Society for Free Radical Research (SFRR), India. January, 2012.
3. Choudhury ST, Mondal A, Das N. Nanoparticulated combination therapy in combating Diethylnitrosamine induced Hepatocarcinoma in rat model. International Conference on Integrative Physiology: Modern Perspective & Platinum Jubilee Celebration of the Physiological Society of India. Organized by: The Physiological Society of India. November, 2009.
4. Choudhury ST, Ghosh A, Das N. Nanoparticulated Quercetin in combating Arsenic induced oxidative damage in Liver and Brain of Rat. Current Trend in Biological Sciences.Organized by: Society of Biological Chemists. September, 2009.
Miss Soni Kumari
Miss Ayendrila Biswas
Dr. Fatema Calcuttawala
Post Doctoral Research at Department of Microbiology, Bose Institute.
Ph.D. in Molecular Microbiology from National Institute of Cholera and Enteric Diseases
GATE 2010 in Life Science
ICMR JRF 2010
CSIR UGC NET 2010 (SPM Fellow)
M.Sc. in Biochemistry from University of Calcutta (Gold Medalist).
B.Sc. in Microbiology from St. Xavier's College.
Genetic Engineering, RDT, Medical Microbiology, Virology, Antibiotics, Immunology.
Soil-dwelling actinomycetes are the most relevant class of microorganisms to expand one’s knowledge on antimicrobial substance production. Most clinically important antibiotics originate from them. However, multidrug resistance is threatening the future continual use of antibiotics. Hence there is a need to develop alternative environmentally friendly processes of nanoparticle synthesis which involves utilization of biological systems as nanofactories thereby promising an environmentally clean, nontoxic and economical process. Dr. Calcuttawala’s research interest is directed at sampling the soil actinomycetes of East Kolkata Wetlands (EKWs) and screening them for antimicrobial substance and nanoparticle production against a wide panel of phytopathogens. The EKWs have been designated as "wetland of international importance" under the Ramsar Convention in 2002. The microbial richness of this region is its hidden asset. Soil samples collected from the wetlands are expected to show the presence of various new strains of actinomycetes which are not only ecologically important but also have commercial value. Furthermore, the nanoparticles synthesized may exhibit a synergistic effect with the antimicrobial substances produced by them and can serve as effective tools in overcoming the roadblock of controlling those phytopathogens which are difficult to eradicate using the conventional agricultural methods.
Elucidation and evaluation of antimicrobial activity andnanoparticle synthesizing potential of soil-dwellingActinomycetesSubmitted for Startup Grant by Department of Science and Technology, Govt. of India.
List of Publications:
1) Sarkar A, Ghosh S, Shaw R, Patra MM, Calcuttawala F, Mukherjee N and Das Gupta SK. 2020. Mycobacterium tuberculosis thymidylatesynthase (ThyX) is a target for plumbagin, anatural product with antimycobacterialactivity. PLoS ONE. 15(2).
2)Calcuttawala F, Hariharan C, Pazhani GP, Saha DR, Ramamurthy T. 2017.Characterization of E-type colicinogenic plasmids from Shigella sonnei. FEMS MicrobiolLett. 364:1-9.
3)Calcuttawala F, Hariharan C, Pazhani GP, Ghosh S, Ramamurthy T. 2015. Activityspectrum of colicins produced by Shigella sonnei and genetic mechanism of colicin resistance in conspecific S. sonnei strains and Escherichia coli. Antimicrob AgentsChemother. 59:152-8.
4) Mitra AK and Calcuttawala F. 2009. Effect of heavy metal contamination on rice pathogenic fungi in reclaimed wetland of East Kolkata in “Phytoremediation andEnvironmental Biotechnology”, Ed.P.C.Trivedi Pointer Publisher, Jaipur. Pp.214.
1) “Electron microscopic evidence for programmed cell death in mycobacteria upon phageD29 infection” at the international conference on "Microbiology in the new Millennium: from Molecules to Communities” at the new Unified Campus of Bose Institute, Kolkata (October 27-29, 2017).
2) “Characterization of Shigella sonnei colicins” at the 9th AnnuconIAMM (IndianAssociation of Medical Microbiologists), West Bengal chapter at NRS Medical College and Hospital, Kolkata (December 7, 2014).
3) “Evidence for Functional Endonuclease Colicin Production by Shigella sonnei” at theConference on Electron Microscopy and XXXIV Annual Meeting of the Electron Microscope Society of India (EMSI), organized in Kolkata (July 3-5, 2013).
4) “Shigella sonnei Colicins and its latent influence in the epidemiology of diarrhea” at a Biochemical Society Focused Meeting: “How bugs kill bugs: Progress and Challenges in bacteriocin research” organized at the University of Nottingham, UK (July 16-18, 2012).
5) “Characteristics of Shigella sonnei Colicins and its Possible Role in Determining the Existence of other Enteric Bacterial Pathogens” at the 46th US-Japan Joint panel meeting held in Kolkata (December 13-15, 2011).
6) “Resveratrol promotes bone formation by augmenting the Wnt signaling pathway: A mechanistic insight” at the Shanti Bhakta Memorial organized in the Department of Biochemistry, University of Calcutta (March, 2010).
7) “Detrimental Effects Of Agricultural Pollutants” at the “National Seminar on Pollution in Urban Industrial Environment ” organized by St. Xavier’s College in association with Institute of Ecotoxicology and Environmental Sciences (2009).
8) “Metal Tolerant Rice Pathogenic Fungi from the Semi-Urban Wetland Environment around Kolkata” in the 95th Indian Science Congress held at Andhra University,Visakhapatnam (2008).
Miss Dooja Singh
Miss Riya Kar
Miss Ankita Pal